![]() ![]() The risk of hypoadiponectinemia with metabolic syndrome was especially increased in men ( P < 0.05). In addition, reductions in adiponectin were associated with increasing metabolic syndrome incidence in a linear dose-response manner. Heterogeneity analysis revealed that an increasing index of insulin resistance was independently associated with improving the performance of adiponectin upon metabolic syndrome diagnosis (ratio of diagnostic odds ratio = 3.89, 95% CI: 1.13–13.9). Adiponectin can identify metabolic syndrome with moderate accuracy (area under the curve = 0.81, 95% CI: 0.77–0.84). Systematic evaluation was performed for diagnostic accuracy and predictivity of adiponectin variation for metabolic syndrome in enrolled studies including 1,248 and 6,020 subjects, respectively. Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. 6Centre for Host–Microbiome Interactions, Dental Institute, King's College London, London, United Kingdom. ![]() 5Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden.4Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.3Department of Pediatrics, Women and Children's Hospital of Guangxi, Nanning, China.2Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.1Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health and Key Laboratory of Organ Transplantation of Zhejiang Province, Hangzhou, China.Zhengtao Liu 1,2 †, Shuheng Liang 3 †, Shuping Que 4, Lin Zhou 1,2, Shusen Zheng 1,2 * and Adil Mardinoglu 4,5,6 * ![]()
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